Science Signaling publishes original Research Articles and Research Resources. Research published in Science Signaling represents major advances in cell signaling, including key research papers in the rapidly expanding areas of cancer, immunology, inflammation, cardiovascular biology, neuroscience, cellular and organismal metabolism, physiology, computational and systems biology, microbiology, host-microbe interactions, plant biology, and the mechanisms of drug action. Research Articles generally report hypothesis-driven research; whereas Research Resources describe nonhypothesis-driven research, including the presentation of new validated tools or techniques or validated databases or data sets relevant to cellular or physiological regulation. Papers are selected for publication in Science Signaling on the basis of their importance and broad interest to scientists engaged in the general area of cellular regulation as determined by the editors in consultation with a Board of Reviewing Editors and in-depth reviewers of papers. Acceptable papers should substantially refine our current understanding of important signaling processes with priority given to those papers that the reviewers and editors determine to provide new concepts and new understanding of biological signal transduction and that are likely to find application in multiple biological systems or in a diverse range of investigations. See the Information for Authors for more details.
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